DEC2 or BHLHE41

"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes, as the name implies, a basic helix-loop-helix protein in various tissues of both humans and mice. It also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. Defects in this gene are associated with the short sleep phenotype. A particular genetic variation in the gene affects sleep duration in humans, and introduction of the human gene into mice also reduces their sleep requirements. This genetic variation was discovered by Ying-Hui Fu's lab.

A Smarter Way to Shop for Eggs

Shopping for eggs? Better bring a glossary. Egg makers are slapping all manner of industry terms on their cartons, some of them meaningful, some of them not. Glossary of egg carton terms:

WHITE / BROWN

The color of the shell is simply that: a color. Different breeds of hens lay different colored eggs, most commonly white or brown but also blue, green, or speckled. Shell color isn’t an indicator of health or flavor or quality—but brown eggs are a lot better for Instagram.

GRADE A / GRADE AA / GRADE B
Eggs are graded according to USDA guidelines. Grade AA and Grade A are practically interchangeable—they indicate eggs that have thick whites, yolks that are free from defects, and clean shells. Grade B is noticeably different: the whites are thin and the shells are blemished. You’ll find Grade A eggs at the grocery store; Grade B is typically reserved for industrial use.

PEEWEE / SMALL / MEDIUM / LARGE / EXTRA LARGE / JUMBO

USDA size standards range from peewee (yes, that’s an actual term) to jumbo. Most recipes call for large eggs, which is good, because that’s what most grocery stores carry. (Peewees, which are the size of quail eggs, are almost impossible to find). Large eggs weigh about 2 ounces and contain approximately 3 1/4 tablespoons of liquid; extra large eggs weigh about 2.25 ounces and have about 4 tablespoons of liquid. Thus, if a recipe only calls for one or two eggs, you can use the two interchangeably with no serious consequences. (Got a recipe that calls for more than two eggs? Start measuring.)

ALL NATURAL
This term isn’t regulated by an agency, so anyone can slap it on their carton and it can mean pretty much whatever the producer wants—there are no standards when it comes to feed, living conditions, or use of antibiotics. In other words, this means nothing. Ignore this.

VEGETARIAN-FED
This means that the chickens were fed a strictly vegetarian diet, which is made up of mostly corn and soybeans. However, this label also suggests that the chickens weren’t allowed to spend any time outside, where they would feed on non-vegetarian grub like worms and other little bugs.

FREE RANGE / CAGE-FREE
Free-range means the chickens are not caged and have some access to the outdoors—though there’s no way of knowing if the chickens actually go outside and if they do, for how long. Cage-free simply means the hens are not caged, but they remain indoors. However, there’s no regulation regarding how much space cage-free chickens actually get.

CERTIFIED ORGANIC
This is the only label that is issued by the USDA. To earn it, eggs must come from free-range chickens that are fed an organic, vegetarian diet.

OMEGA-3

A regular egg has about 30mg of heart healthy omega-3 fatty acid, while an egg with this label is fed a diet enriched with fish oil and flaxseed to have an even higher amount. How much higher? The egg producers aren’t required to say, so you’ll never know.

GSLV Mk-III

GSLV Mk-III Lift Off - Sriharikota

Work Out As You Will

Swimming is the best exercise. No, wait, walking is. Hmm, how about yoga? That’s good and safe for everyone, right? So what’s the official word on that? Just like there’s no ‘right man/ ideal woman’ to get married to, it changes in each phase of our life, there is no ‘best’ exercise. But, unlike relationships, with exercise, you have the option of moving from one to another without a sense of guilt or betrayal. The ‘best’ exercise is one that engages you physically, mentally, emotionally, and on levels even deeper than that. It is something that you look forward to on a daily basis, it is the reason you eat dinner on time, it is the reason you hit the bed early. It is the reason you wake up even before your alarm goes off. It makes you feel beautiful inside out, it keeps you young, makes you smile, fall in love with yourself all over again. Yes, the ‘right’ exercise has that magical effect on all of us, it can calm our nerves, sharpen our memory, erase those worry lines, flatten that bulge under the eye and over the stomach and make you light and contented like a happy child. It is up to us to seek the ‘right’ exercise, because there are no set rules on how to keep the body in top shape. Information so authoritatively dispensed by various newspapers and tabloids, or at a bout of party gossip, can’t rule our heads or heart when it comes to making decisions about our workout. Some of us will find it in yoga, some of us in running, some find it in pumping iron and others while biking at dawn. The question is, are you searching?

Schizophrenia

Schizophrenia is a mental disorder characterized by a breakdown of thought processes and by poor emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. Diagnosis is based on observed behavior and the patient's reported experiences. A person diagnosed with schizophrenia may experience hallucinations (most reported are hearing voices), delusions (often bizarre or persecutory in nature), and disorganized thinking and speech. The latter may range from loss of train of thought, to sentences only loosely connected in meaning, to incoherence known as word salad in severe cases. Social withdrawal, sloppiness of dress and hygiene, and loss of motivation and judgment are all common in schizophrenia. There is often an observable pattern of emotional difficulty, for example blunted affect. Impairment in social cognition is associated with schizophrenia, as are symptoms of paranoia; social isolation commonly occurs. In one uncommon subtype, the person may be largely mute, remain motionless in bizarre postures, or exhibit purposeless agitation, all signs of catatonia.

Bipolar disorder

Bipolar disorder is a condition in which people go back and forth between periods of a very good or irritable mood and depression. The "mood swings" between mania and depression can be very quick. Bipolar disorder or manic–depressive disorder, also referred to as bipolar affective disorder or manic depression, is a psychiatric diagnosis that describes a category of mood disorders defined by the presence of one or more episodes of abnormally elevated energy levels, cognition, and mood with or without one or more depressive episodes. The elevated moods are clinically referred to as mania or, if milder, hypomania. Individuals who experience manic episodes also commonly experience depressive episodes, or symptoms, or a mixed state in which features of both mania and depression are present at the same time. These events are usually separated by periods of "normal" mood; but, in some individuals, depression and mania may rapidly alternate, which is known as rapid cycling. Extreme manic episodes can sometimes lead to such psychotic symptoms as delusions and hallucinations. The disorder has been subdivided into bipolar I, bipolar II, cyclothymia, and other types, based on the nature and severity of mood episodes experienced; the range is often described as the bipolar spectrum.

Estimates of the lifetime prevalence of bipolar disorder vary, with studies typically giving values of the order of 1%, with higher figures given in studies with looser definitions of the condition. The onset of full symptoms generally occurs in late adolescence or young adulthood. Diagnosis is based on the person's self-reported experiences, as well as observed behavior. Episodes of abnormality are associated with distress and disruption and an elevated risk of suicide, especially during depressive episodes. In some cases, it can be a devastating long-lasting disorder. In others, it has also been associated with creativity, goal striving, and positive achievements. There is significant evidence to suggest that many people with creative talents have also suffered from some form of bipolar disorder. It is often suggested that creativity and bipolar disorder are linked.

Genetic factors contribute substantially to the likelihood of developing bipolar disorder, and environmental factors are also implicated. Bipolar disorder is often treated with mood stabilizing medications and, sometimes, other psychiatric drugs. Psychotherapy also has a role, often when there has been some recovery of the subject's stability. In serious cases, in which there is a risk of harm to oneself or others, involuntary commitment may be used. These cases generally involve severe manic episodes with dangerous behavior or depressive episodes with suicidal ideation. There are widespread problems with social stigma, stereotypes, and prejudice against individuals with a diagnosis of bipolar disorder. People with bipolar disorder exhibiting psychotic symptoms can sometimes be misdiagnosed as having schizophrenia, another serious mental illness.

The current term bipolar disorder is of fairly recent origin and refers to the cycling between high and low episodes (poles). A relationship between mania and melancholia had long been observed, although the basis of the current conceptualisation can be traced back to French psychiatrists in the 1850s. The term "manic-depressive illness" or psychosis was coined by German psychiatrist Emil Kraepelin in the late nineteenth century, originally referring to all kinds of mood disorder. German psychiatrist Karl Leonhard split the classification again in 1957, employing the terms unipolar disorder (major depressive disorder) and bipolar disorder.

The Millionaire Mindset

There are key differences between the way rich people look at money and the way the rest of us do:

•Wealthy people look at money in positive terms and as an opportunity, where as most of us live in fear of being laid off or not having enough money for retirement.
•Instead of worrying about running out of money, soon to be millionaires are thinking how to make more money. World-class performers are finding problems that are profitable to solve. They know that just because a solution hasn't been discovered yet doesn't mean it doesn't exist.
•Millionaires tend to move towards what they want, rather than move away from what they don't want, which is what the masses most often do.
•World-class thinkers have the guts to be optimistic right now in these shaky times and reject the middle-class cynicism that plagues the masses. It's not comfortable for a millionaire in the making to forge ahead when everyone around him or her is negative, cynical and unsupportive, yet the great ones push forward and are rewarded with riches for the rest of their lives.

Bottom line: "Take inventory of your consciousness and the way you think about money and ask yourself: Is this the way a rich person thinks or someone in the middle class thinks about money?"

You need to know about her

You need to know about her
you can feel her care in the form of a sister
you can feel her innocence in d form of a daughter
You can feel her warmth in the form a friend
You can feel her passion in the form a beloved

Dedication in the form of wife
Divinity in the form of mother
Blessings in the form of grandma
Yes she is so tough too
Her heart is so tender
So naughty
So charming
So sharing
So melodious
She is woman.
She is life
you are in this world because of her
you may not devote her
at least respect her

i will wait for you

as i lay here now,
your image stays with me.
although you're gone,
you're far away from me.
my heart paints your picture,
my imagination creates your smile.
my memory replays your eyes,
the way you laughed.
silently speaking to me,
you'll always be part of me,
although you're so far away,
in time we'll be together,
but until then i will wait for you.

Let Go Of Yourself And Speak Up! (Love Secret)

WHY do people hesitate to confess their love? True love is non reciprocal in nature, we all just hope to be lucky enough to receive it in return from that special person. Why would you choose to hold on to a gift that is not yours to begin with? That love belongs in the heart of someone else. Why withhold something so beautiful and essential to life from the person you claim to love? It does no one any good keeping it locked up tight. Why would you choose to live with the endless questions and doubts instead of seeking an answer that could lead you to happiness? The only answer to all of these is ego: fear of rejection, jealousy, possessiveness, and such. Once we let go of our own ego, quietly loving someone who cannot return it becomes a beautiful thing. Trust me! :)

Invest in the Future: Cut Hunger in Half

No one is immune from the worsening global economic crisis, but some had very little to lose even before the crisis hit. One in seven people around the world go to bed hungry each night — and they're finding it even harder to feed themselves and their families.

Here in the World, our governments found the money to bail out banks and insurance companies when they got into trouble. We must also bank on investing critical resources in the one billion people around the world who can't get enough to eat.

Hunger isn't only an empty feeling in the belly; it also creates gaping holes in communities. Malnutrition impairs a child’s ability to learn and a parent’s ability to earn a living, making it more difficult to break the cycle of hunger and poverty.

The ravages of hunger don't only cost them dearly, it also costs us. Chronic hunger erases an estimated $30 billion per year in productivity from the global economy. If you multiply that over the lifespan of the children who don’t get enough to eat today, the World Food Programme projects that cost could top a trillion dollars.

You can help mitigate the human costs of hunger. Ask government to invest in a healthy and productive future for all children. Tell them to support a federal budget that funds a comprehensive effort to fight hunger and poverty around the world. Do your parts to make sure families never have to go to bed hungry again.

Why do we shout in anger?

A saint asked his disciples, 'Why do we shout in anger? Why do people shout at each other when they are upset? Disciples thought for a while, one of them said, 'Because we lose our calm, we shout for that.' 'But, why to shout when the other person is just next to you?' asked the saint. 'Isn't it possible to speak to him or her with a soft voice? Why do you shout at a person when you're angry?' Disciples gave some other answers but none satisfied the saint. Finally he explained, 'When two people are angry at each other, their hearts distance a lot. To cover that distance they must shout to be able to hear each other. The angrier they are, the stronger they will have to shout to hear each other through that great distance.' Then the saint asked, 'What happens when two people fall in love? They don't shout at each other but talk softly, why? Because their hearts are very close. The distance between them is very small...' the saint continued, 'When they love each other even more, what happens? They do not speak, only whisper and they get even closer to each other in their love. Finally they even need not whisper, they only look at each other and that's all. That is how close two people are when they love each other.' MORAL: When you argue do not let your hearts get distant, do not say words that distance each other more, else there will come a day when the distance is so great that you will not find the path to return.

Music

Music

Music is my Inspiration.When I write. Even when I program.
Music gives me energy, makes me smile, and in some cases : it helps me mourn and heal.
Overall, I don't think I could picture my life without it.

Written for The Beautiful people
.

Become a millionaire with the Latte Factor

That small sum you spend each day in small pleasures of life, such as complementing your lunch with a beverage, or snacks and latte in the evening, or even calls on your cellphone is what tends to snowball into a huge amount that gets torn out of your savings each month.

Consider, for instance, the following representative figures:

Latte at the coffee-shop: Rs 30
A cold drink: Rs 20
Mobile phone usage: Rs 20
Samosas, biscuits, crisps or other snacks: Rs 40

This sum of Rs 110 a day amounts to Rs 3300 every month and in a year, about Rs 40,000.
And if one saves this Rs 110 every day, one could become a millionaire over the next 30 years.
The way to make that come true is to work on the Latte Factor.

The term, coined by David Bach, is named after the coffee which you buy at the neighbourhood cafe, instead of putting aside that money for a rainy day. Bach sums up in monetary terms the things people are addicted to, so you simply add up the cost of small expenses, such as lattes at a coffee shop, to see what they amount to.For more and more people, these small indulgences are becoming tantamount to an addiction. Psychologist Bhawna Bamr says, "It's addiction where we feel pride in possessing things which others don't have." She adds that shopping gives her that vicarious pleasure. The Latte Factor shows that we often have way more money than we think; it's just that bit by bit we spend it on a lot of small things. The way to combat this startling outflow is to keep track of small expenses.

"Maintain a daily diary on what all you have on today," says psychologist Vaid Jain. "That expenditure will soon lessen." A good thumb-rule is calculating small expenses sedulously. If it comes to more than 10 per cent of your salary, then it's time to crack the whip on your spending habits.

Love is in the year

February 14th is a day that you either love or loath because lovers all over the world exchange cards, flowers and gifts. But have you ever thought where the tradition comes from - here is a brief history of St Valentine's Day so you can find out! Eight hundred years before the first Valentine's Day, the Romans practised a festival celebrating sexual pleasure and fertility. Observing a young man's rite of passage, a girl's name would be randomly drawn and the pair would be partners for the year. In 496 AD Pope Gelasius decided he didn't like this practise and allowed both men and women to draw the name of a Saint from a box, which they had to follow for the rest of the year.

The decision was unpopular, forcing Pope Gelasius to come up with a patron saint of love – which is where Valentine comes in. Emperor Claudius II (known as Claudius the Cruel) believed that married men made bad soldiers because they didn't want to leave their wives, so Claudius prohibited all marriages in the Empire. Valentine, a Christian Priest, secretly married young couples, leading to his inevitable imprisonment and eventual death in 270 AD. While incarcerated it is believed that Valentine fell in love with the jailer's blind daughter, and her sight was miraculously restored through his love for her and his strong faith.

Before he was stoned to death and beheaded, he wrote her a note, signed ‘from your Valentine', a phrase used today by millions of people across the world to send an anonymous card to their lover. The Roman men accepted this, and the tradition became to send a handwritten message of affection, containing Valentine's name, to your loved one on February 14th, the day Valentine was killed. Not quite as passionate as the pagan festival, but very romantic. If you're after someone's amorous attention you'd better get scribbling now – you don't want to miss out!

Including You

A story is told about a soldier who was finally coming home after having fought in War. He called His parents. “Mummy and Daddy, I’m coming home, but I’ve got a favor to ask. I have a Friend I’d like to bring with me.” “Sure,” they replied, “we’d love to meet him.” “There’s something you should know,” the son continued, “He was hurt pretty badly in the fighting. He stepped on a landmine and lost an arm and a leg. He has nowhere else to go, and I want him to come live with us.” “I’m sorry to hear that, son. Maybe we can help him find somewhere to live.” “No, Mom and Dad, I want him to live with us.” “Son,” said the father, “you don’t know what you’re asking. Someone with such a handicap would be a terrible burden on us. We have our own lives to live, and we can’t let something like this interfere with our lives. I think you should just come home and forget about this guy. He’ll find a way to live on his own.”

At that point, the son hung up the phone. The parents heard nothing more from him. A few days later, however, they received a call from the police. Their son had died after falling from a building, they were told. The police believed it was suicide. The grief- stricken parents flew to and were taken to the city morgue to identify the body of their son. They recognized him, but to their horror they also discovered something they didn’t know, their son had only one arm and one leg. The parents in this story are like many of us. We find it easy to love those who are good-looking or fun to have around, but we don’t like people who inconvenience us or make us feel uncomfortable. We would rather stay away from people who aren’t as healthy, beautiful, or smart as we are.

Thankfully, there’s someone who won’t treat us that way. Someone who loves us with an unconditional love that welcomes us into the forever family, regardless Of how messed up we are. Tonight, before you tuck yourself in for the night, say a little prayer that God will give you the strength you need to accept people as they are, and to help us all be more understanding of those who are different from us!!! There’s a magic called -Friendship- that dwells deep in the heart. You don’t know how it happens or when it gets its start. But you know the special lift it always brings and you realize that Friendship Is God’s most precious gift! Friends are a very rare jewel, indeed. They make you smile and encourage you to succeed. They lend an ear, they share a word of praise, and they always want to open their hearts to us.

International Men’s Day

The objectives of celebrating an International Men’s Day include improving gender relations, promoting gender equality, producing responsible males and highlighting positive male role models. The observance of International Men's Day seeks to address problems and challenges facing men. These issues include the involvement of men in domestic violence, drug abuse, fathering, homicides, sports, media, power, politics, religion, parenting, war, suicides and family life. The ultimate goal of the Men’s Day is to promote unity and create a safer, better world. This community was made to address and seek solutions for the problems facing males in today's society.

Individuals, international associations, non-governmental organizations (NGOs) and religious bodies will be contacted to assist in the observance of this special day. There is also a need for the regular hosting of international conferences on men to address issues and seek solutions. Hopefully, in the long-term we can make International Men's Day an annual worldwide event with beneficial results. It is hoped that men interested in improving themselves and reforming other males would be part of this ongoing "Men's Revolution" and annually celebrate International Men's Day.
At work, in our communities, schools and religious institutions, there should be dialogue between both sexes for greater understanding and tolerance. Thanks for your support and advice in this endeavor as we strive for gender equality and attempt to remove the negative images and the stigma associated with men in our society.

Onward Men of the World

Sons, fathers, brothers, daughters, mothers and sisters, come join the uphill struggle for peace and equality. It will take decades, centuries, probably longer than we expect. But let us keep the faith and persist. Cooperating and consolidating, until our dream is achieved, until we display and receive respect. Discussing, discovering and enforcing. Our remedies for ills and issues will strengthen society’s sinews. A fire has been lit, and a movement for positive change quickens its pace. So accept the baton as a global revolution commences.

A Vision for Peace and Equality. Come men of the world, young and old, belonging to different classes, religions and races. Let us unite forces to change cold hearts and unhappy faces. A world of wars and violence must be no more. Yes, we regret a sad past of violence and gore. Let us rid ourselves of vices many, for the betterment of our womenfolk, children and peace of society. We strive to be role models for the next generation, bringing joy and goodwill to countries, towns and families. Daily we battle temptations and evils, the victors must assist the losers. As together we strengthen our resolve to create a better world.

Men's Code of Conduct

I wanted to share a wonderful Men’s Code of Conduct that was developed on Gender, Family, and Community Violence.

Men's Institute Code Of Conduct

• I recognize that silence is not acceptable and that words alone are not enough, I must act.
• I will put my family first; before friends, community and even self. I will love, protect and provide for my family.
• I will model love and tenderness for my children, spouse/ partner, parents and community.
• I will work to make my home a place of safety and security for my family - A Sanctuary.
• I will be a positive role model for my own family, children and community.
• I commit to showing and sharing my emotions and feelings openly and honestly.
• I will acknowledge my own mistakes and learn from them.
• I am willing to say "I'm sorry" when I make a mistake; and I will show through my actions that I mean it.
• I am willing to learn, change and grow.
• I will act in a manner that is respectful of myself and others.
• I will celebrate my own history and culture, as well as those of others.
• I will be accountable for unearned male privilege and strive for gender equality and equity.
• I recognize that domestic violence is a community issue, affecting everyone, including men and generations to come.
• I will support the development of education across cultures regarding domestic violence as it relates to contemporary societal norms and laws.
• I will support community organizations that provide assistance to families, victims and perpetrators.
• I will help deliver the message that violence is never an appropriate means of communication or problem solving.
• I refuse to abuse.
With a spirit of love and hope, I affirm that I will live by this code, and that I will encourage others to adopt it as well.

Being Female

My happiness about being female goes hand in hand with my relief not to be male. Yes indeed. Allow me to elaborate.
· Being female means not having to watch lame sports. Unless I want to.
· Being female means I'm allowed to cry. It makes me sensitive rather than a wet blanket.
· Being female means not having to go where my dick mindlessly leads me. That's right, 'cause I ain't got one.
· Being female means having the right to bitch and whine before, during and right after my period. Not to mention when I'm ovulating. Face it, boys, there's no way in hell you could blame temporary let alone chronic moodiness on mister one-eye.
· Being female means you can like disco without anyone remarking "are you a woofer, or what?!!"
· Being female means understanding the joy of shopping. You boys don't know what you're missing.
· Being female means not having to worry about going bald. We just go gray and dye, and don't have to resort to wigs. Unless we want to.
· Being female means the ability to have kids if we want them. In the real world, not even Arnie could pull that one off.
· Being female means having friends, rather than booze-buddies.
· Being female means not having to be macho. Unless I want to.
· Being female means not being judged on your car. Or the bimbo by your side.
· Being female at 40 means good sex. Being male aged 40.. what was sex again?
· Being female means never being ashamed or afraid to hug your friends.
· Being female means never being too embarrassed to tell mum you love her.
Let's face it, people. Would anyone voluntarily be a man?
Originally written for "Something To Say". Try not to take it TOO seriously.

Tears and Love

She said love is a dream. He said love is a sham. She said love was life. He said love is a farce. She said love is divine. He said love is evil. They were diversity brought together. She was a dreamer, he a realist. But what they had in common was respect for each other. And of course, they were friends.

For the rest, it was a wonder how they got along so well. When mentioned, she used to give a wry smile and he, used to just roll his eyes. But they did get along so well. After all they were supposed to be mature and grown up when it came to relationships.

She was a prankster. He was very serious. She loved to make faces, talk like a kid, fool around and majorly have fun. He was just the opposite. For him, work was worship. She loved to have more friends. He kept to his old friends. Cherished them, and was willing to die for them. She had loads of friends, and kept forgetting people’s names when they called her up. He used to shout at her. She was not the one used with being shouted at. But she understood that he meant her well. And used to accept him, as he was. This did not mean that they did not have fights between themselves. They fought teeth and nail. The walked away from each other like bitter enemies. But they always came back together. And their friends used to say “Heavens alone know why and when”!

Then, she had to go to a distant place. And she found that he was a part of her life. But she kept it to herself. Because she was bound to another by marriage. As they stood at the check in counter of the airport, they shook hands, parting way as friends do. Both knew, they may never see themselves again. She did not make an eye contact with him till she walked past the security gate. But then she could not control herself, she looked back, and their eyes met. And in his eyes, she saw a tear. A tear which said that he had changed his views on love.

Truely Beautiful

Many women may feel insecure in terms of beauty, but I want to say something to them. Beauty is not related with your age, nor is it with physical appearance to the people who loves you. Beauty of women lies not in the curves of her body, nor in the crowning glory, niether in the things she wear. Beauty lies in the caring she shows to everybody around. The divinity she has as a nurturer, as a mother. The duty she shows towards her partner. The forgiveness she teaches...The sacrifices she makes. So all the women out there...don’t fell into the trap of feeling insecure about the way u look...Age gracefully...and be beautiful within...because that beauty doesn’t get mellowed down with age...it only increases! So wear your inner beauty and feel the beauty of life and universe. The recipe for beauty is to have less illusion and more Soul, to retreat from the belief of pain or pleasure in the body into the unchanging calm and glorious freedom of spiritual harmony.Belive that beauty is not real, it only exists in perception of...